Domain Generalization (DG) aims to enable models to generalize to unseen target domains by learning from multiple source domains. Existing DG methods primarily rely on convolutional neural networks (CNNs), which inherently learn texture biases due to their limited receptive fields, making them prone to overfitting source domains. While some works have introduced transformer-based methods (ViTs) for DG to leverage the global receptive field, these methods incur high computational costs due to the quadratic complexity of self-attention. Recently, advanced state space models (SSMs), represented by Mamba, have shown promising results in supervised learning tasks by achieving linear complexity in sequence length during training and fast RNN-like computation during inference. Inspired by this, we investigate the generalization ability of the Mamba model under domain shifts and find that input-dependent matrices within SSMs could accumulate and amplify domain-specific features, thus hindering model generalization. To address this issue, we propose a novel SSM-based architecture with saliency-based token-aware transformation (namely START), which achieves state-of-the-art (SOTA) performances and offers a competitive alternative to CNNs and ViTs. Our START can selectively perturb and suppress domain-specific features in salient tokens within the input-dependent matrices of SSMs, thus effectively reducing the discrepancy between different domains. Extensive experiments on five benchmarks demonstrate that START outperforms existing SOTA DG methods with efficient linear complexity.

Deep Neural Networks (DNNs) suffer from domain shift when the test dataset follows adistribution different from the training dataset. Domain generalization aims to tackle this issue by learning a model that can generalize to unseen domains.

However, selecting intermediate domains without explicit metadata remains a substantial challenge that has not been extensively explored in existing studies. T o tackle this issue, we propose a novel framework that combines reinforcement learning with feature disentanglement to conduct domain path selection in an unsupervised CDA setting. Our approach introduces an innovative unsupervised reward mechanism that leverages the distances between latent domain embeddings to facilitate the identification of optimal transfer paths. Furthermore, by disentangling features, our method facilitates the calculation of unsupervised rewards using domain-specific features and promotes domain adaptation by aligning domain-invariant features. This integrated strategy is designed to simultaneously optimize transfer paths and target task performance, enhancing the effectiveness of domain adaptation processes. Extensive empirical evaluations on datasets such as Rotated MNIST and ADNI demonstrate substantial improvements in prediction accuracy and domain selection efficiency, establishing our method's superiority over traditional CDA approaches.

In this paper, we theoretically analyze the generalization error bound of the Mamba model under domain shifts.

The intricate morphology of brain vessels poses significant challenges for automatic segmentation models, which usually focus on a single imaging modality. However, accurately treating brain-related conditions requires a comprehensive understanding of the cerebrovascular tree, regardless of the specific acquisition procedure. Our framework effectively segments brain arteries and veins in various datasets through image-to-image translation while avoiding domain-specific model design and data harmonization between the source and the target domain. This is accomplished by employing disentanglement techniques to independently manipulate different image properties, allowing them to move from one domain to another in a label-preserving manner. Specifically, we focus on manipulating vessel appearances during adaptation while preserving spatial information, such as shapes and locations, which are crucial for correct segmentation. Our evaluation effectively bridges large and varied domain gaps across medical centers, image modalities, and vessel types. Additionally, we conduct ablation studies on the optimal number of required annotations and other architectural choices. The results highlight our framework's robustness and versatility, demonstrating the potential of domain adaptation methodologies to perform cerebrovascular image segmentation in multiple scenarios accurately. Our code is available at https://github.com/i-vesseg/MultiVesSeg.